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Polymer Chemistry

Prof. Peter Walde

Peter Johann Walde

ETH Zürich
Prof. Dr. Peter Johann Walde
Institut f. Polymere
HCI G 527
Wolfgang-Pauli-Str. 10
8093 Zuerich

Phone: +41 44 632 04 73
Fax: +41 44 632 12 65

Curriculum Vitae

1956 November 24, born at Martigny, Switzerland

1975 – 1979 Study in chemistry at ETH Zurich: Diploma as chemist (“Dipl. Chem. ETH”)

1980 – 1983 Ph. D. studies at ETH Zurich, group of Prof. Pier Luigi Luisi: Ph. D. in natural sciences (“Dr. sc. nat. ETH”). Dissertation on the characterization of bee venom peptides and proteolytic enzymes from sunflower seeds.

1983 – 1984 Postdoc at ETH, group of Prof. Pier Luigi Luisi. Work on a novel trypsin inhibitor from white mustard seeds.

1984 – 1985 Postdoc at University of Auckland, New Zealand, group of Prof. Charmian J. O’Connor (Fellowship of Auckland University). Work on the activity of human milk lipase.

1985 – 1986 Postdoc at University of Nagasaki, Japan, group of Prof. Junzo Sunamoto (Fellowship from the Matsumae International Foundation). Work on the effect of bile salts on liposomes and on the activity of human milk lipase.

1986 – 2004 ETH, Biopolymer group of Prof. Pier Luigi Luisi.

1986 – 1988: “Assistant”. Work on lipases and proteases solubilized in reverse micelles.

1989 – 1991: “Oberassistant”. Work on enzymes in reverse micelles, on self-replicating micelles and on the use of organogels for transdermal drug delivery.

1992: Completion of the habilitation at the division of Chemistry (“Privatdozent”). “Venia legendi” for Supramolecular Chemistry. Work on enzymatic reactions in lipid vesicles and on self-reproducing vesicles.

1997: Received the title of professor from ETH (“Titularprofessor”). Work on the preparation and application of large and giant lipid vesicles as reaction systems. Studies of basic aspects of fatty acid vesicles and on vesicles as hypothetical precursor structures of the first cells.

since 2004 ETH, Polymer Chemistry group of Prof. A. Dieter Schlüter. Work on the enzymatic polymerization and on the preparation of dendronized polymer-enzyme conjugates.

Current research interests

- Use of vesicles as templates and compartments for enzymatic polymerization reactions
- Preparation of hybrid structures between dendronized polymers and enzymes (for possible bioanalytical applications)
- Use of vesicles as biomimetic compartment systems

Selected recent publications

Kuroiwa, T.; Fujita, R.; Kobayashi, I.; Uemura, K.; Nakajima, M.; Sato, S.; Walde, P.; Ichikawa, S., Chem. Biodiv. 9, 2453-2472 (2012): Efficient Preparation of Giant Vesicles as Biomimetic Compartment Systems with High Entrapment Yields for Biomacromolecules.

Grotzky, A.; Nauser, T.; Erdogan, H.; Schlüter, A. D.; Walde, P., J. Am. Chem. Soc. 134, 11392 – 11395 (2012). A Fluorescently Labeled Dendronized Polymer-Enzyme Conjugate Carrying Multiple Copies of Two Different Types of Active Enzymes.

Junker, K.; Zandomeneghi, G.; Guo, Z.; Kissner, R.; Ishikawa, T.; Kohlbrecher, J.; Walde, P., RSC Advances 2, 6478-6495 (2012). Mechanistic aspects of the horseradish peroxidase-catalysed polymerisation of aniline in the presence of AOT vesicles as templates.

Fornera, S.; Bauer, T.; Schlüter, A. D.; Walde, P., J. Mater. Chem. 22, 502-511 (2012). Simple enzyme immobilization inside glass tubes for enzymatic cascade reactions.

Fornera, S.; Kuhn, P.; Lombardi, D.; Schlüter, A. D.; Dittrich, P. S.; Walde, P., ChemPlusChem 77, 98-101 (2012). Sequential immobilization of enzymes in microfluidic channels for cascade reactions.

Liebi, M.; Kohlbrecher, J.; Ishikawa, T.; Fischer, P.; Walde, P.; Windhab, E. J., Langmuir 28, 10905-10915 (2012). Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueosu Mixture of DMPC and DMPE-DTPA with Complexed Thullium Ions.

Guo, Z.; Hauser, N.; Moreno, A.; Ishikawa, T.; Walde, P., Soft Matter 7, 180-193 (2011). AOT vesicles as templates for the horseradish peroxidase-triggered polymerization of aniline.

Walde, P.; Guo, Z., Soft Matter 7, 316-331 (2011). Enzyme-catalyzed chemical structure-controlling template polymerization.

Dejanović, B.; Noethig-Laslo, V.; Šentjurc, M.; Walde, P., Chem. Phys. Lipids 164, 83-88 (2011). On the surface properties of oleate micelles and oleic acid/oleate vesicles studied by spin labeling.

Fornera, S.; Yazawa, K.; Walde, P., Anal. Bioanal. Chem. 401, 2307-2310 (2011). Spectrophotometric quantification of lactose in solution with a peroxidase-based enzymatic cascade reaction system.

Fornera, S.; Balmer, T. E.; Zhang, B.; Schlüter, A. D.; Walde, P., Macromol. Biosci. 11, 1052-1067 (2011). Immobilization of peroxidase on SiO2 surfaces with the help of a dendronized polymer and the avidin-biotin system.

Grotzky, A.; Manaka, Y.; Kojima, T.; Walde, P., Biomacromolecules 12, 134-144 (2011). Preparation of catalytically active, covalent α-polylysine-enzyme conjugates via UV/Vis-quantifiable bis-aryl hydrazone bond formation.

Beck, P.; Liebi, M.; Kohlbrecher, J.; Ishikawa, T.; Rüegger, H.; Fischer, P.; Walde, P.; Windhab, E., Langmuir, 26, 5382-5387 (2010). Novel Type of Bicellar Disks from a Mixture of DMPC and DMPE-DTPA with Complexed Lanthanides.

Beck, P.; Liebi, M.; Kohlbrecher, J.; Ishikawa, T.; Rüegger, H.; Zepik, H.; Fischer, P.; Walde, P.; Windhab, E., J. Phys. Chem. B 114, 174-186 (2010). Magnetic Field Alignable Domains in Phospholipid Vesicle Membranes Containing Lanthanides.

Walde, P., BioEssays, 32, 296-303 (2010). Building artificial cells and protocell models: experimental approaches with lipid vesicles (Commentary).

Walde, P.; Cosentino, K.; Engel, H.; Stano, P., ChemBioChem, 11, 848-865 (2010). Giant Vesicles: Preparations and Applications.

Fornera, S.; Walde, P., Anal. Biochem. 407, 293-295 (2010). Spectrophotometric quantification of horseradish peroxidase with o-phenylenediamine.

Grotzky, A.; Manaka, Y.; Fornera, S.; Willeke, M.; Walde, P., Anal. Methods 2, 1448-1455 (2010). Quantification of α-polylysine: a comparison of four UV/Vis spectrophotometric methods.

Peterlin, P.; Arrigler, V.; Kogej, K.; Svetina, S.; Walde, P., Chem. Phys. Lipids 159, 67-76 (2009). Growth and shape transformations of giant phospholipid vesicles upon interaction with an aqueous oleic acid suspension.

Shimanouchi, T.; Walde, P.; Gardiner, J.; Capone, S.; Seebach, D.; Kuboi, R., ChemBioChem 10, 1978-1981 (2009). Inversion of the Configuration of a Single Stereocenter in a β-Heptapeptide Leads to Drastic Changes in Its Interaction with Phospholipid Bilayers.

Guo, Z.; Rüegger, H.; Kissner, R.; Ishikawa, T.; Willeke, M.; Walde, P., Langmuir 25, 11390-11405 (2009). Vesicles as Soft Templates for the Enzymatic Polymerization of Aniline.

List of Publications


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